What is Agomelatine?
Category: Prescription Drugs
Most popular types: Valdoxan
Agomelatine, (trade names Valdoxan, Melitor, Thymanax) is a melatonergic antidepressant not currently available in the US. Due to its unique profile it has not been associated with weight gain, sexual side effects, or withdrawal syndrome as experienced with other antidepressants.
| Purpose | Patients | Evaluations | Perceived Effectiveness |
|---|---|---|---|
| Major depressive disorder | 26 | 16 | |
| Depressed mood | 13 | 10 | |
| Insomnia | 9 | 7 | |
| Anxious mood | 4 | 5 | |
| Fibromyalgia | 3 | 3 | |
| Panic attacks | 2 | 3 |
- Major
- Moderate
- Slight
- None
- Can't tell
Side effects
Side effects as an overall problem
| Severity | Evaluations | Percentage |
|---|---|---|
| Severe | 3 | |
| Moderate | 4 | |
| Mild | 8 | |
| None | 22 |
Commonly reported side effects and conditions associated with Agomelatine
| Side effect | Patients | Percentage |
|---|---|---|
| Anxious mood | 2 | |
| Constipation | 1 | |
| Difficulty thinking | 1 | |
| Difficulty with orgasm | 1 | |
| Dizziness | 1 | |
| Insomnia | 1 |
Duration
Stopped taking Agomelatine
| Duration | Patients | Percentage |
|---|---|---|
| Less than 1 month | 3 | |
| 1 - 6 months | 3 | |
| 6 months - 1 year | 8 | |
| 1 - 2 years | 3 | |
| 2 - 5 years | 1 |
What people switch to and from
Patients started taking Agomelatine after stopping:
| Treatment | Patients | Percentage |
|---|---|---|
| Escitalopram (Lexapro) | 3 | |
| Duloxetine (Cymbalta) | 2 | |
| Aripiprazole (Abilify) | 1 | |
| Desvenlafaxine (Pristiq) | 1 | |
| Sertraline (Zoloft) | 1 |
Patients stopped taking Agomelatine and switched to:
| Treatment | Patients | Percentage |
|---|---|---|
| Duloxetine (Cymbalta) | 2 | |
| Dosulepin (Dothep) | 1 | |
| Mirtazapine (Remeron) | 1 | |
| Sertraline (Zoloft) | 1 | |
| Trazodone (Apo-Trazodone) | 1 |
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