What is Carbidopa-Levodopa CR?
Category: Prescription Drugs
Most popular types: Sinemet CR Carbilev Half Sinemet CR Show all
A controlled release preparation of carbidopa/levodopa formulated to release a lower, smoother dose of medication. It is sometimes taken last thing at night in order to maintain dopamine levels throughout sleep and into the morning.
| Purpose | Patients | Evaluations | Perceived Effectiveness |
|---|---|---|---|
| Parkinson's disease | 331 | 170 | |
| Stiffness/spasticity | 40 | 17 | |
| Improve mobility | 15 | 10 | |
| Slow movement (bradykinesia) | 6 | 1 | |
| Tremor in hands | 6 | 3 |
- Major
- Moderate
- Slight
- None
- Can't tell
Side effects
Side effects as an overall problem
| Severity | Evaluations | Percentage |
|---|---|---|
| Severe | 12 | |
| Moderate | 31 | |
| Mild | 38 | |
| None | 123 |
Commonly reported side effects and conditions associated with Carbidopa-Levodopa CR
| Side effect | Patients | Percentage |
|---|---|---|
| Jerky movements | 13 | |
| Vivid dreams | 10 | |
| Fatigue | 8 | |
| Nausea | 7 | |
| Amber colored urine | 4 | |
| Back pain | 4 |
Why patients stopped taking Carbidopa-Levodopa CR
Multiple reasons could be selected
| Reason | Patients | Percentage |
|---|---|---|
| Doctor's advice | 39 | |
| Did not seem to work | 24 | |
| Other | 20 | |
| Side effects too severe | 13 | |
| Personal research | 5 | |
| Course of treatment ended | 3 | |
| Change in health plan coverage | 1 | |
| Expense | 1 |
Duration
Stopped taking Carbidopa-Levodopa CR
| Duration | Patients | Percentage |
|---|---|---|
| Less than 1 month | 11 | |
| 1 - 6 months | 20 | |
| 6 months - 1 year | 7 | |
| 1 - 2 years | 17 | |
| 2 - 5 years | 17 | |
| 5 - 10 years | 12 | |
| 10 years or more | 5 |
What people switch to and from
Patients started taking Carbidopa-Levodopa CR after stopping:
| Treatment | Patients | Percentage |
|---|---|---|
| Carbidopa-Levodopa (Sinemet) | 13 | |
| Carbidopa-Entacapone-Levodopa (Stalevo) | 3 | |
| Carbidopa Levodopa ER (Rytary XR) | 3 | |
| Amantadine (Symmetrel) | 1 | |
| Apomorphine (Apokyn) | 1 |
Patients stopped taking Carbidopa-Levodopa CR and switched to:
| Treatment | Patients | Percentage |
|---|---|---|
| Carbidopa-Levodopa (Sinemet) | 10 | |
| Carbidopa Levodopa ER (Rytary XR) | 5 | |
| Carbidopa-Entacapone-Levodopa (Stalevo) | 2 | |
| Acetaminophen (Paracetamol) (Tylenol) | 1 | |
| Apomorphine (Apokyn) | 1 |
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