What is Denosumab?
Category: Prescription Drugs
Most popular types: Prolia Xgeva
Denosumab is a monoclonal antibody that is used for the treatment of osteoporosis, bone loss associated with certain cancer treatments, and the prevention of bone loss from cancer that has spread to the bone. It is given by an injection under the skin.
| Purpose | Patients | Evaluations | Perceived Effectiveness |
|---|---|---|---|
| Osteoporosis | 43 | 23 | |
| Bone metastases | 12 | 5 | |
| Osteopenia | 4 | 0 | |
| Bowel urgency | 1 | 1 | |
| Giant cell tumor of the bone | 1 | 1 |
- Major
- Moderate
- Slight
- None
- Can't tell
Side effects
Side effects as an overall problem
| Severity | Evaluations | Percentage |
|---|---|---|
| Severe | 5 | |
| Moderate | 3 | |
| Mild | 6 | |
| None | 15 |
Commonly reported side effects and conditions associated with Denosumab
| Side effect | Patients | Percentage |
|---|---|---|
| Heartburn | 2 | |
| Bone pain | 1 | |
| Cyclic vomiting syndrome | 1 | |
| Diarrhea | 1 | |
| Fatigue | 1 | |
| Generalized weakness (asthenia) | 1 |
Why patients stopped taking Denosumab
Multiple reasons could be selected
| Reason | Patients | Percentage |
|---|---|---|
| Side effects too severe | 2 |
Duration
Stopped taking Denosumab
| Duration | Patients | Percentage |
|---|---|---|
| Less than 1 month | 1 | |
| 2 - 5 years | 1 | |
| 5 - 10 years | 1 |
What people switch to and from
Patients started taking Denosumab after stopping:
| Treatment | Patients | Percentage |
|---|---|---|
| Alendronate (Fosamax) | 5 | |
| Risedronate (Actonel) | 4 | |
| Raloxifene (Evista) | 2 | |
| Calcitonin-salmon (Fortical) | 1 | |
| Ibandronate (Boniva) | 1 |
Patients stopped taking Denosumab and switched to:
| Treatment | Patients | Percentage |
|---|---|---|
| Zoledronic acid (Zometa) | 2 | |
| Alendronate (Fosamax) | 1 |
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