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What is SAMe (S-adenosyl-L-methionine)?

Category: Supplements

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S-adenosyl-L-methionine (SAMe) is an amino acid. As a supplement it's use is promoted for depression, osteoarthritis, and cholestasis of pregnancy and intrahepatic cholestasis associated with liver disease.

See patients taking SAMe (S-adenosyl-L-methionine)

Reported purpose & perceived effectiveness
Purpose Patients Evaluations Perceived Effectiveness
Depressed mood 43 23
Fibromyalgia 21 12
General health 10 5
Major depressive disorder 6 2
Anxious mood 4 3

Show all 44 reasons taken

  • Major
  • Moderate
  • Slight
  • None
  • Can't tell
See all 284 patients that have taken SAMe (S-adenosyl-L-methionine)

Side effects

Side effects as an overall problem

Side effects as an overall problem
Severity Evaluations Percentage
Severe 7
Moderate 7
Mild 10
None 43

Commonly reported side effects and conditions associated with SAMe (S-adenosyl-L-methionine)

Side effect Patients Percentage
Stomach pain 3
Headaches 2
Anxious mood 1
Bipolar manic episodes 1
Depressed mood 1
Dry throat 1

Show all 19 reported side effects

Why patients stopped taking SAMe (S-adenosyl-L-methionine)

Multiple reasons could be selected

Reason Patients Percentage
Did not seem to work 19
Other 17
Expense 16
Side effects too severe 11
Doctor's advice 3
Personal research 3
Course of treatment ended 2
See all 53 patients who've stopped taking SAMe (S-adenosyl-L-methionine)

Duration

Stopped taking SAMe (S-adenosyl-L-methionine)

Duration Patients Percentage
Less than 1 month 13
1 - 6 months 23
6 months - 1 year 9
1 - 2 years 2
2 - 5 years 4
5 - 10 years 2
Adherence
Adherence Evaluations Percentage
Always 48
Usually 16
Sometimes 3
Never taken as prescribed 0
Burden
Burden Evaluations Percentage
Very hard to take 5
Somewhat hard to take 8
A little hard to take 17
Not at all hard to take 37
Cost per month
Cost per month Evaluations Percentage
$200+ 0
$100-199 0
$50-99 9
$25-49 23
< $25 11
Not specified 24
Last updated:

7 patient evaluations for SAMe (S-adenosyl-L-methionine)

Sort by: Most recent

Jan 17, 2012 (Started Dec 23, 2011)

  • Effectiveness
    None (for Treat my mood condition(s))
  • Side effects
    Mild (depressed mood)
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 400 mg Daily
Advice & Tips: Pellentesque habitant morbi tristique senectus et netus et malesuada fames ac turpis egestas. Phasellus faucibus turpis sed mi maximus mattis.
  • 0 helpful marks

Jun 20, 2011 (Started Mar 15, 2011)

  • Effectiveness
    Can't tell (for amyotrophic lateral sclerosis)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    Not at all hard to take
Dosage: 400 mg Daily
Cost: < $25 monthly
  • 0 helpful marks

Jun 14, 2010 (Started Aug 24, 2009)

  • Effectiveness
    Slight (for Joint health)
  • Effectiveness
    Moderate (for depressed mood)
  • Side effects
    None
  • Adherence
    Always
  • Burden
    A little hard to take
Dosage: 400 mg Daily
Advice & Tips: Pellentesque habitant morbi tristique senectus et netus et malesuada fames ac turpis egestas. Phasellus faucibus turpis sed mi maximus mattis.
Cost: $25-49 monthly
  • 0 helpful marks
Last updated:
Showing 3 of 7 patient evaluations for SAMe (S-adenosyl-L-methionine)