What is Trihexyphenidyl?
Category: Prescription Drugs
Most popular types: Artane Trihexyphen Pacitane Show all
See also: Risperidone-Trihexyphenidyl Rispond Plus
Trihexyphenidyl is anti-Parkinson's and anticholinergic agent used as adjunctive treatment of Parkinson's disease and for the treatment of drug-induced extrapyramidal symptoms.
| Purpose | Patients | Evaluations | Perceived Effectiveness |
|---|---|---|---|
| Parkinson's disease | 88 | 50 | |
| Tremor in hands | 30 | 22 | |
| Tremor(s) | 24 | 26 | |
| Torticollis | 10 | 0 | |
| Dystonia | 5 | 6 | |
| Restlessness (akathisia) | 5 | 4 |
- Major
- Moderate
- Slight
- None
- Can't tell
Side effects
Side effects as an overall problem
| Severity | Evaluations | Percentage |
|---|---|---|
| Severe | 19 | |
| Moderate | 32 | |
| Mild | 29 | |
| None | 28 |
Commonly reported side effects and conditions associated with Trihexyphenidyl
| Side effect | Patients | Percentage |
|---|---|---|
| Cognitive confusion | 10 | |
| Dry mouth | 9 | |
| Word fishing | 6 | |
| Dizziness | 4 | |
| Sleepiness | 4 | |
| Auditory hallucinations | 2 |
Why patients stopped taking Trihexyphenidyl
Multiple reasons could be selected
| Reason | Patients | Percentage |
|---|---|---|
| Side effects too severe | 30 | |
| Doctor's advice | 20 | |
| Did not seem to work | 18 | |
| Other | 10 | |
| Course of treatment ended | 3 | |
| Personal research | 3 | |
| Expense | 1 |
Duration
Stopped taking Trihexyphenidyl
| Duration | Patients | Percentage |
|---|---|---|
| Less than 1 month | 6 | |
| 1 - 6 months | 21 | |
| 6 months - 1 year | 11 | |
| 1 - 2 years | 11 | |
| 2 - 5 years | 11 | |
| 5 - 10 years | 1 | |
| 10 years or more | 3 |
What people switch to and from
Patients started taking Trihexyphenidyl after stopping:
| Treatment | Patients | Percentage |
|---|---|---|
| Baclofen (Mylan-Baclofen) | 1 | |
| Benztropine (Cogentin) | 1 | |
| Biperiden (Akineton) | 1 | |
| Cyclobenzaprine (Flexeril) | 1 | |
| Gabapentin (Neurontin) | 1 |
Patients stopped taking Trihexyphenidyl and switched to:
| Treatment | Patients | Percentage |
|---|---|---|
| Carbidopa-Levodopa (Sinemet) | 5 | |
| Amantadine (Symmetrel) | 2 | |
| Entacapone (Comtan) | 2 | |
| Baclofen (Mylan-Baclofen) | 1 | |
| Cyclobenzaprine (Flexeril) | 1 |
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