What is Zoledronic acid?
Category: Prescription Drugs
Most popular types: Zometa Reclast
Zoledronic acid is a bisphosphonate used in the treatment of hypercalcemia of malignancy (albumin-corrected serum calcium ≥12 mg/dL), multiple myeloma, bone metastases of solid tumors, Paget's disease of bone, postmenopausal osteoporosis.
| Purpose | Patients | Evaluations | Perceived Effectiveness |
|---|---|---|---|
| Osteoporosis | 112 | 33 | |
| Multiple myeloma | 54 | 16 | |
| Osteopenia | 11 | 11 | |
| Bone metastases | 5 | 2 | |
| Bone pain | 5 | 1 | |
| Paget's disease of bone | 4 | 0 |
- Major
- Moderate
- Slight
- None
- Can't tell
Side effects
Side effects as an overall problem
| Severity | Evaluations | Percentage |
|---|---|---|
| Severe | 5 | |
| Moderate | 6 | |
| Mild | 4 | |
| None | 37 |
Commonly reported side effects and conditions associated with Zoledronic acid
| Side effect | Patients | Percentage |
|---|---|---|
| Bone pain | 2 | |
| Fever/chills | 2 | |
| Abdominal cramps | 1 | |
| Broken leg (right) | 1 | |
| Contact dermatitis | 1 | |
| Extreme flu like malaise | 1 |
Why patients stopped taking Zoledronic acid
Multiple reasons could be selected
| Reason | Patients | Percentage |
|---|---|---|
| Doctor's advice | 12 | |
| Course of treatment ended | 7 | |
| Side effects too severe | 5 | |
| Other | 3 | |
| Change in health plan coverage | 1 | |
| Did not seem to work | 1 | |
| Expense | 1 |
Duration
Stopped taking Zoledronic acid
| Duration | Patients | Percentage |
|---|---|---|
| Less than 1 month | 2 | |
| 1 - 6 months | 2 | |
| 6 months - 1 year | 1 | |
| 1 - 2 years | 8 | |
| 2 - 5 years | 6 | |
| 5 - 10 years | 2 | |
| 10 years or more | 1 |
What people switch to and from
Patients started taking Zoledronic acid after stopping:
| Treatment | Patients | Percentage |
|---|---|---|
| Alendronate (Fosamax) | 2 | |
| Denosumab (Prolia) | 2 | |
| Pamidronate (Aredia) | 2 | |
| Alendronate-cholecalciferol (Fosamax plus D) | 1 | |
| Amitriptyline (Elavil) | 1 |
Patients stopped taking Zoledronic acid and switched to:
| Treatment | Patients | Percentage |
|---|---|---|
| Denosumab (Prolia) | 1 | |
| Etanercept (Enbrel) | 1 | |
| Pamidronate (Aredia) | 1 | |
| Raloxifene (Evista) | 1 | |
| Trazodone (Apo-Trazodone) | 1 |
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