What is Dornase alfa?
Category: Prescription Drugs
Most popular types: Pulmozyme
Dornase alfa is an enzyme used with cystic fibrosis patients to reduce the frequency of respiratory infections that require IV antibiotics; in conjunction with standard therapies, it is used to improve pulmonary function in patients with cystic fibrosis.
| Purpose | Patients | Evaluations | Perceived Effectiveness |
|---|---|---|---|
| Cystic fibrosis | 770 | 12 | |
| Coughing up phlegm | 1 | 0 |
- Major
- Moderate
- Slight
- None
- Can't tell
Side effects
Side effects as an overall problem
| Severity | Evaluations | Percentage |
|---|---|---|
| Severe | 2 | |
| Moderate | 2 | |
| Mild | 0 | |
| None | 11 |
Commonly reported side effects and conditions associated with Dornase alfa
| Side effect | Patients | Percentage |
|---|---|---|
| Coughing up blood (hemoptysis) | 2 | |
| Excess mucus | 1 | |
| Fever/chills | 1 | |
| Sore throat | 1 |
Duration
Stopped taking Dornase alfa
| Duration | Patients | Percentage |
|---|---|---|
| Less than 1 month | 1 | |
| 1 - 6 months | 4 | |
| 6 months - 1 year | 1 | |
| 1 - 2 years | 1 | |
| 2 - 5 years | 1 | |
| 5 - 10 years | 3 | |
| 10 years or more | 2 |
What people switch to and from
Patients started taking Dornase alfa after stopping:
| Treatment | Patients | Percentage |
|---|---|---|
| Hypertonic Saline (MucoClear) | 1 |
Patients stopped taking Dornase alfa and switched to:
| Treatment | Patients | Percentage |
|---|---|---|
| N-Acetylcysteine NAC (GNC N-Acetyl Cysteine) | 1 |
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