What is Methylfolate (l-methylfolate)?
Category: Supplements
Most popular types: Deplin Metanx
Methylfolate, or l-methylfolate, is the active form of folate in the body. Folate is necessary for formation of numerous coenzymes in many metabolic systems.
| Purpose | Patients | Evaluations | Perceived Effectiveness |
|---|---|---|---|
| Increase effect of another treatment | 67 | 29 | |
| Major depressive disorder | 42 | 32 | |
| Depressed mood | 38 | 12 | |
| Methylenetetrahydrofolate reductase deficiency | 21 | 9 | |
| Fatigue | 8 | 3 | |
| Myalgic encephalomyelitis/chronic fatigue syndrome | 4 | 7 |
- Major
- Moderate
- Slight
- None
- Can't tell
Side effects
Side effects as an overall problem
| Severity | Evaluations | Percentage |
|---|---|---|
| Severe | 3 | |
| Moderate | 3 | |
| Mild | 8 | |
| None | 104 |
Commonly reported side effects and conditions associated with Methylfolate (l-methylfolate)
| Side effect | Patients | Percentage |
|---|---|---|
| Dizziness | 1 | |
| Dysphoric mania | 1 | |
| Food allergy | 1 | |
| Insomnia | 1 | |
| Irritability | 1 | |
| None | 1 |
Why patients stopped taking Methylfolate (l-methylfolate)
Multiple reasons could be selected
| Reason | Patients | Percentage |
|---|---|---|
| Did not seem to work | 28 | |
| Expense | 18 | |
| Other | 12 | |
| Doctor's advice | 8 | |
| Course of treatment ended | 5 | |
| Side effects too severe | 4 | |
| Change in health plan coverage | 3 |
Duration
Stopped taking Methylfolate (l-methylfolate)
| Duration | Patients | Percentage |
|---|---|---|
| Less than 1 month | 6 | |
| 1 - 6 months | 26 | |
| 6 months - 1 year | 6 | |
| 1 - 2 years | 10 | |
| 2 - 5 years | 7 | |
| 5 - 10 years | 5 | |
| 10 years or more | 1 |
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